Deoxyribonucleic Acid Biosynthesis in Mitochondria
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چکیده
منابع مشابه
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria.
Fatty acid and lipoic acid biosynthesis were investigated in plant mitochondria. Although the mitochondria lack acetyl-CoA carboxylase, our experiments reveal that they contain the enzymatic equipment necessary to transform malonate into the two main building units for fatty acid synthesis: malonyl- and acetyl-acyl carrier protein (ACP). We demonstrated, by a new method based on a complementary...
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Recently, our laboratory reported the detection of small amounts of DNA in lamb heart mitochondria (1, 2). Experimental evidence indicated that this DNA was not merely a contaminant, but fulfilled a biologically active role in mitochondrial protein synthesis (2, 3). This was established by the observation that a DNA-dependent RNA polymerase was present in the mitochondria (2, 4, 5). These obser...
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Triostin antibiotics, which contain a cyclic peptide with a disulphide bridge, have been prepared by growing Streptomyces triostinicus in the presence of inorganic [3PS]sulphate. The labelled triostin A has been shown to behave in all respects similarly to the authentic natural product and to enable a much more sensitive radiochemical adaptation of the solvent-partition method for determining a...
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The effects of the three antibiotics U-12,241, nogalamycin, and U-20,661 on (i) deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis in KB cell cultures and cell-free systems of bacterial and mammalian origin and on (ii) oxidative phosphorylation in rat liver mitochondria were compared. Nogalamycin and U-12,241 inhibited RNA synthesis more strongly than DNA synthesis in all test sys...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63014-5